New: prescription low-dose naltrexone capsules, from $119 billed once. The price is on this page.
CLYR Health / Daily Wellness / Low-Dose Naltrexone
New at CLYR · Prescription low-dose naltrexone

Low-dose naltrexone, prescribed and compounded for you.

Prescribed off-label for long-running conditions such as fibromyalgia, MS and Crohn's. Is it relevant to me?

Pharmaceutical-grade 4.5mg capsules, one at bedtime, written by a licensed U.S. provider after a short online screening. From $119, billed once, no subscription.

Check my eligibility

90 capsules for $169, provider review and shipping included.

CLYR compounded low-dose naltrexone 4.5mg capsule
4.5mg capsulesOne at bedtime
30 or 90 capsulesOne bottle, one box
Pharmaceutical-gradeU.S. 503A compounded
Billed onceNo subscription
Licensed U.S. providers
Licensed U.S. 503A pharmacy
Shipping included, plain box
Billed once, nothing renews
Quick question

What are you after?

Is LDN relevant to me? What low-dose naltrexone actually is How it is taken, and what to expect Ready to start, show me the prices

Tapping an option just moves you to the right part of this page. It is not a medical assessment. The real questionnaire happens after you pick a plan.

Who it is for

Who is LDN prescribed for?

Low-dose naltrexone is not FDA-approved for any condition at this dose. Providers prescribe it off-label, and it has been studied for, and is commonly prescribed for, a handful of long-running conditions.

Most studied

Fibromyalgia

The most-studied use, including small placebo-controlled trials at Stanford.

Quality of life

Multiple sclerosis

Studied mainly for quality of life and fatigue.

Small trials

Crohn's disease

Small trials at Penn State and a Cochrane review that called the evidence limited.

Clinical experience

Hashimoto's thyroiditis

Mostly clinical experience and case reports so far; no controlled trial yet.

Since 2022

Long COVID

Early open-label studies; larger trials are under way.

Active research

Chronic pain and inflammation

Other chronic pain and inflammatory conditions, an active area of research with mostly small studies.

It is usually considered by adults with a long-running condition who are already working with a clinician and want to discuss another option. It does not replace your current care. Your provider decides whether it is appropriate for you.

Why people look into it

LDN is an old, inexpensive, well-understood medicine. People also like that it is one capsule at bedtime and that the side effects reported in studies were mostly mild, such as vivid dreams or lighter sleep. Some patients report changes in how they feel day to day. Others notice nothing. Every human is different, and CLYR does not promise results.

One strength, one capsule a night

Naltrexone at a low dose, written by your provider.

Naltrexone is a medicine that has been prescribed for decades at 50mg. Low-dose naltrexone, usually called LDN, is the same molecule compounded at a small fraction of that, here as 4.5mg capsules, made to your prescription by a licensed U.S. 503A pharmacy. Doses this low are not sold as a commercial product, which is why it is compounded.

4.5mg The strength
The low dose CLYR offers, and the dose used in several published LDN trials. Your provider decides whether it is appropriate and writes the directions.
30 or 90 capsules
Bedtime When
One capsule at night. Lighter sleep or vivid dreams in the first weeks have been reported; tell your provider if they bother you.
One capsule a night
Your provider Who decides
A licensed U.S. provider reviews your screening and every medicine you take before anything is written. If LDN is not appropriate for you, you are refunded in full.
Review included
Safety first The screening
Some medicines and health conditions rule LDN out. Your screening checks for them before a provider reviews anything; the full list is in the Important Safety Information.
Screened first

Every human is different, and CLYR does not promise what LDN will do for you. What we promise is a licensed provider, a real prescription, a licensed pharmacy and a clear price.

Transparent price

Pick your pack. Billed once.

Every bottle is 4.5mg capsules, one at bedtime, with the provider review and shipping included. Nothing renews.

4.5mg · 30 capsules
$119
Starter · one at bedtime · billed once
  • Provider review included, no visit fee
  • Shipping included, plain box
  • Reorder any time from your portal
  • Nothing renews automatically
Start with 30 capsules
Best value · save $188
4.5mg · 90 capsules
$169
90 capsules in one box · billed once
  • $1.88 a capsule instead of $3.97
  • Provider review included, no visit fee
  • Shipping included, plain box
  • Nothing renews automatically
Get 90 capsules

Prices are per bottle, billed once. Capsule count is the quantity in the bottle; your provider writes the directions and the days of supply. Important safety information

How it works

From questionnaire to doorstep.

1

Answer the questionnaire

Health history and every medicine you take, including pain medicines. About five minutes, and finishing it costs nothing.

2

A licensed provider decides

They confirm LDN is appropriate for you and write the prescription with the directions they choose. If it is not appropriate, you are refunded in full.

3

Compounded and shipped

A licensed U.S. 503A pharmacy compounds your 4.5mg capsules to the prescription and ships them tracked in a plain box, usually within a few business days of approval.

4

One capsule at bedtime

As directed on your pharmacy label. Questions along the way go to your provider through your portal.

A fifty-year-old medicine. A low dose, written for you.

What low-dose naltrexone is

An old medicine at a small dose, explained plainly.

Naltrexone was approved in the 1980s as the standard FDA-approved 50 mg tablet. In the 1980s and 1990s physicians began prescribing it off-label at a small fraction of that dose, which is what people mean by LDN. At that dose it is active in the body only briefly. CLYR's capsules are pharmaceutical-grade naltrexone compounded at 4.5mg by a licensed U.S. pharmacy, prescribed by a licensed provider.

Where it came from

Naltrexone has been a prescription medicine since 1984. The low-dose protocol grew out of clinical practice in New York in the mid 1980s and has been used off-label ever since.

What it does in the body

At 4.5mg naltrexone is active for a few hours and then clears. Researchers have proposed an endorphin rebound and a calming effect on immune cells in the nervous system. Both are working theories from small studies, explained below.

Why it is compounded

No manufacturer sells a 4.5mg naltrexone capsule. A licensed 503A pharmacy makes it to your prescription, which is why it is a prescription at CLYR and not an over-the-counter product.

What CLYR does not say

CLYR does not claim LDN will treat, cure or improve any condition. Every human is different. Your provider can talk through what is known and what is not.

How it is thought to work

Two working theories, not settled science.

At 50 mg, naltrexone is active all day. At 4.5 mg it is active for only a few hours overnight and then clears. Researchers have proposed two effects.

1. An endorphin rebound

The brief block may lead the body to make more of its own endorphins and become more sensitive to them.

2. Calmer immune cells

Low doses appear to act on receptors (TLR4) on microglia, the immune cells of the nervous system, which are linked to inflammation and pain signaling.

These are working theories from lab and early clinical research, not settled science.

What the research says

Most LDN research is small: pilot studies, crossover trials and case series. Larger trials are under way. These are the studies people ask about.

  1. FibromyalgiaYounger J, Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Med. 2009, PMID 19453963
  2. FibromyalgiaYounger J et al. Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels. Arthritis Rheum. 2013, PMID 23359310
  3. Multiple sclerosisCree BA et al. Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis. Ann Neurol. 2010, PMID 20695007
  4. Crohn's diseaseSmith JP et al. Low-dose naltrexone therapy improves active Crohn's disease. Am J Gastroenterol. 2007, PMID 17222320
  5. Crohn's disease, reviewSegal D et al. Low dose naltrexone for induction of remission in Crohn's disease. Concluded the evidence is limited. Cochrane Database Syst Rev. 2014, PMID 24558033
  6. Long COVIDO'Kelly B et al. Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study. Brain Behav Immun Health. 2022, PMID 35814187
  7. How it may workYounger J, Parkitny L, McLain D. The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clin Rheumatol. 2014, PMID 24526250

Results across these studies were mixed, and none makes LDN an approved treatment. Your provider can go through what is known for your situation. Hashimoto's has no controlled trial yet, so none is cited.

LegitScript Certified
Medically reviewed by the CLYR clinical teamLast reviewed October 29, 2026. Studies checked against PubMed on that date.
Prescribed by licensed U.S. providersCompounded to your prescription by a state-licensed 503A pharmacy. Compounded medications are not FDA-approved.
What to expect

One capsule at bedtime, and a provider who stays on it.

Your dose

4.5 mg, one capsule at bedtime. 4.5 mg is the standard low dose, and your provider writes the directions.

The first few weeks

Vivid dreams, lighter sleep, headache or nausea are the most commonly reported side effects, and they usually settle. If they do not, message your provider.

Over time

In studies, people were followed for 8 to 12 weeks or longer. Many patients choose the 90-capsule bottle so they have time to see how it goes with their provider.

Follow-up

Your provider is in your portal for questions, and every reorder is reviewed.

Price

$119 for 30 capsules or $169 for 90, billed once. Provider review and shipping are included. Nothing auto-renews.

Check my eligibility See both packs
Learn more

Read before you decide.

Plain-English guides from the CLYR journal, with the studies linked.

LDN for fibromyalgiaWhat the trials found, including the Stanford crossover study. LDN and multiple sclerosisWhat the quality-of-life trials show. LDN and Hashimoto'sWhat the evidence says, and what it does not. LDN and long COVIDThe early studies since 2022, and their limits. Why 4.5 mgWhat the published studies used, and why one strength. Side effectsWhat the studies reported, week by week. LDN vs the 50 mg tabletSame molecule, different dose, different product. What LDN costsWhat is in the price, and how to compare. How to get LDN onlinePrescription, pharmacy and cost, step by step. The plain-English guideWhat LDN is, what it is not, and what the evidence says.
What arrives

A plain box. On purpose.

Discreet packaging

The outer box carries no product name and no condition anywhere on the label. Neighbors and roommates learn nothing.

Your statement reads CLYR Health

Not a pharmacy name, not a product name. Just CLYR Health.

The full term in one shipment

We ship everything at once, at room temperature. No repeat pharmacy runs, no waiting on a refill that should already be there.

The CLYR standard

No hidden price. No surprise renewals. No mystery pharmacy.

CLYR Health is LegitScript certified, treatments are reviewed by licensed providers, and every compounded product comes from a state-licensed pharmacy. The price you see on this page is the price you pay, and when your term ends the next decision is yours.

LegitScript Certified
HIPAA Compliant
Licensed Providers
State-Licensed Pharmacy
Questions

Answered plainly.

Low-dose naltrexone is not FDA-approved for any condition at this dose. Providers prescribe it off-label, and it has been studied for, and is commonly prescribed for, fibromyalgia, multiple sclerosis, Crohn's disease, Hashimoto's thyroiditis, long COVID and other chronic pain and inflammatory conditions. Results in studies were mixed, and CLYR does not claim LDN will treat any of them. The plain-English guide goes through the evidence.

Naltrexone is available as the standard FDA-approved 50 mg tablet. Low-dose naltrexone, or LDN, is the same molecule prescribed off-label at a much smaller dose. No manufacturer makes a capsule that small, so a licensed 503A pharmacy compounds it to your prescription. At CLYR it is a 4.5mg capsule, written by a licensed U.S. provider.

No. Naltrexone is available as the standard FDA-approved 50 mg tablet, but compounded low-dose naltrexone is not FDA-approved. A licensed U.S. 503A pharmacy makes the 4.5mg capsule to your provider's prescription, and the provider prescribes it off-label after reviewing your screening and the medicines you take.

Some medicines and health conditions rule LDN out, including liver disease, hepatitis or abnormal liver tests, and a known allergy to naltrexone. The full list, including the medicines that cannot be combined with naltrexone, is in the Important Safety Information below. Tell your provider about kidney disease, pregnancy, breastfeeding or plans for pregnancy, and about every medicine and supplement you take.

One 4.5mg capsule by mouth at bedtime, or exactly as your provider directs. 4.5mg is the low dose CLYR offers, and your licensed provider decides whether it is appropriate for you. Your provider's directions are on the pharmacy label and in your portal.

Side effects reported with low-dose naltrexone include vivid dreams, trouble sleeping, headache and nausea. Dizziness and anxiety are also listed in the Important Safety Information. If anything bothers you or does not ease, message your provider from your portal. Your provider can review the directions and decide what happens next.

There is no fixed answer. In published studies people were followed for 8 to 12 weeks or longer before results were measured, and many patients choose the 90-capsule bottle for that reason. Your provider is in your portal to help you judge, and CLYR does not promise results.

Some medicines cannot be combined with naltrexone; the full list is in the Important Safety Information below. For everything else, your provider reviews your complete medication list during screening, so list every medicine you take, including thyroid medication or MS treatments, and the provider decides whether LDN is appropriate alongside them.

Same molecule, different dose and a different product. The 50 mg tablet is a manufactured, FDA-approved medicine. LDN is naltrexone compounded at 4.5mg by a state-licensed 503A pharmacy to your prescription, prescribed off-label and not FDA-approved at this dose. The difference is explained in LDN vs the standard 50 mg tablet.

Low-dose naltrexone has been studied for several decades, mostly in small trials and case series. It is an active area of research rather than a settled one, and CLYR does not make claims about what it will do for you. Every human is different. The studies people ask about are listed on this page, and your provider can talk through what is known.

$119 for 30 capsules or $169 for 90 capsules, each billed once. That covers the capsules, the licensed provider's review of your screening and medications, the pharmacy's compounding and shipping. Nothing renews, and your provider sets the days of supply. If the provider decides LDN is not appropriate for you, you are refunded in full.

Thirty capsules is the smaller pack. Ninety is the same capsules in one box at $169, which is $1.88 a capsule instead of $3.97. Capsule count is the quantity in the bottle; your provider writes the days of supply.

No. The screening is online and the provider reviews it. If the provider has a question, you hear from them through your portal or email.

We ship to most states and Puerto Rico. The screening tells you right away if we cannot ship to yours.

Yes. Reorder from your portal any time; the provider reviews each order.

You pay at checkout, and if the reviewing provider decides LDN is not appropriate for you, you are refunded in full.

From $119 for 30 capsules, billed once.

Start with the questionnaire.

Five minutes, online, and no card required to finish it. Your provider writes the directions.

Check my eligibility

Important Safety Information

Compounded low-dose naltrexone is a prescription capsule dispensed only after a licensed provider independently reviews your intake and determines it is appropriate for you. Do not take naltrexone if you take any opioid medicine or have taken one in the last 14 days, including tramadol, codeine, methadone or buprenorphine, because naltrexone blocks them and can cause sudden withdrawal; do not take it if you currently take or need opioid medicines, have liver disease, hepatitis or abnormal liver tests, or are allergic to naltrexone. Tell your provider about kidney disease, pregnancy, breastfeeding or plans for pregnancy, and about every medication and supplement you take. Side effects may include vivid dreams, trouble sleeping, headache, nausea, dizziness or anxiety. Carry a note that you take naltrexone, because opioid pain medicines may not work normally while it is in your system. Compounded medications are made by a licensed U.S. 503A pharmacy to a provider's prescription; they are not FDA-approved and have not been reviewed by the FDA for safety or effectiveness. Individual results vary. Not everyone qualifies. This page is informational and is not medical advice. Call 911 in an emergency.

$1694.5mg, 90 capsules, billed once
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