CLYR Health  /  Weight Loss  /  Semaglutide
Best Value
Semaglutide vial
Weight Loss, Compounded Injectable

Semaglutide.

A GLP-1 receptor agonist compounded by a state-licensed 503A pharmacy. Combined with Vitamin B12 for energy and metabolic support. Once-weekly subcutaneous injection. The most prescribed weight loss GLP-1 in the world.

$225 /month

Starting dose. Any dose, same price. Includes provider consultation, medication, syringes, and free expedited shipping.

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Semaglutide compounded with Vitamin B12 (multi-dose vial)
Injection homekit (syringes, alcohol pads, sharps container)
Licensed provider consultation included
Dose titration support: 0.25mg, 0.5mg, 1mg, 1.7mg, 2.4mg
Free expedited cold-chain shipping
Ongoing provider care and dose management
Benefits

The most prescribed GLP-1.
Now compounded for value.

Semaglutide is the active ingredient in Ozempic and Wegovy. It reduces appetite, slows gastric emptying, and improves insulin response. Our compounded version pairs it with Vitamin B12.

Once weekly

One self-administered subcutaneous injection per week. Most patients give themselves the shot in under a minute.

13 to 15% weight loss

In the STEP-1 trial, patients on semaglutide 2.4mg lost an average of 14.9 percent of their body weight over 68 weeks.

Reduced appetite

Slows gastric emptying so you feel full longer. Most patients report craving less food and stopping at smaller portions.

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B12 for energy

Vitamin B12 supports red blood cell production, neurological function, and energy metabolism. Helps offset fatigue during titration.

Most prescribed

Semaglutide is the most widely prescribed GLP-1 in the world. Decades of safety data, clear titration pathway.

Any dose, same price

Whether you are on 0.25mg or the full 2.4mg, you pay the same. No price increases as you titrate up.

Dosing Schedule

A gradual titration for your body to adjust.

Most patients start at 0.25mg per week and titrate up every 4 weeks. Your provider will guide you based on your response and tolerability.

Month 1
0.25 mg
Week 1 to 4
Month 2
0.5 mg
Week 5 to 8
Month 3
1 mg
Week 9 to 12
Month 4 plus
Up to 2.4 mg
Adjusted by provider
What's Included

Everything you need,
delivered.

Your $225 a month covers the medication, supplies, provider consultation, ongoing care, and shipping. No hidden fees, no surprise charges.

Semaglutide + B12 vial

Multi-dose vial compounded at a state-licensed 503A pharmacy. Combined with Vitamin B12 for energy and metabolic support.

Injection homekit

Syringes, alcohol pads, and a sharps disposal container. Most patients self-administer in under a minute after a short tutorial.

Provider consultation

A licensed provider reviews your health profile, BMI, and goals. Adjusts your dose at each titration step.

Free cold-chain shipping

Discreet, temperature-safe packaging. Ships within 1 to 3 business days of provider approval.

FAQs

Common questions.

Ozempic (approved for type 2 diabetes) and Wegovy (approved for chronic weight management) are brand-name semaglutide made by Novo Nordisk. Compounded semaglutide is made by a state-licensed 503A pharmacy to a custom formula. Both contain semaglutide as the active ingredient, but compounded medications are not FDA-approved. CLYR offers both options so you can choose what works best for you.

Most patients see meaningful appetite reduction within the first 2 weeks. Visible weight loss typically begins by week 4 to 6. The most significant results come over 6 to 12 months of consistent treatment combined with sustainable eating and movement habits.

The most common side effects are gastrointestinal: nausea, diarrhea, constipation, and reduced appetite. These usually peak in the first 2 weeks of each dose increase and subside as your body adjusts. Less common but serious side effects include pancreatitis, gallbladder issues, and (in rare cases) thyroid tumors in patients with a personal or family history of medullary thyroid cancer or MEN-2.

Anyone with a personal or family history of medullary thyroid carcinoma or MEN-2, severe gastroparesis, active pancreatitis, or a history of severe allergic reaction to semaglutide. Pregnant or breastfeeding women should also avoid it. Your provider will screen for all of these at consultation.

Semaglutide can interact with insulin and sulfonylureas (raising hypoglycemia risk), oral contraceptives (slowing absorption due to delayed gastric emptying), and warfarin. Always tell your provider everything you take, including over-the-counter and supplements.

Without ongoing treatment, appetite typically returns and most patients regain weight unless they have built sustainable habits. Many patients use semaglutide as a long-term tool combined with lifestyle changes. Your provider can also help you taper safely if you choose to stop.

Both work. In head-to-head trials, tirzepatide produced more weight loss on average but came with slightly higher GI side effects. Semaglutide has a longer track record and is often the right starting point. Your provider will discuss your goals, medical history, and budget to recommend the best fit.

Ready to start?

5-minute health questionnaire. Provider review. Free expedited shipping. No insurance hassles.

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