Ask CLYR: To get LDN online, you complete a health screening, a licensed provider reviews it, and if appropriate a compounding pharmacy prepares and ships the capsules. At CLYR, LDN 4.5 mg is $119 for 30 capsules or $169 for 90 capsules, billed once, and ships to most states and Puerto Rico.
Low-dose naltrexone (LDN) is a compounded capsule, not FDA-approved at this dose, and prescribed off-label. That means you cannot buy it over the counter, and a regular pharmacy will not have it on the shelf. You need a licensed provider to prescribe it and a licensed compounding pharmacy to make it. Telehealth has made both steps simpler. This guide walks through how it works at CLYR and what to check in any service you consider. If you are new to LDN, start with what low-dose naltrexone is.
The short answer
You complete an online health screening. A licensed provider reviews it, including every medicine you take. If the provider decides LDN is appropriate, a licensed U.S. compounding pharmacy prepares 4.5 mg capsules and ships them to you. CLYR ships to most states and Puerto Rico. When you are ready, you can start your LDN screening.
Step by step at CLYR
- Health screening. You answer questions about your health history, conditions and current medicines. Some medicines and conditions rule LDN out, so those are checked first. The cautions are explained in LDN side effects and who should not take it.
- Provider review. A licensed provider reviews your answers independently. If something needs clarifying, the provider contacts you. The provider decides whether LDN is appropriate for you. Not everyone qualifies.
- Compounding. If LDN is prescribed, a state-licensed 503A compounding pharmacy prepares 4.5 mg capsules to the prescription. Your provider writes the directions, typically one capsule nightly or as your provider directs.
- Shipping. The pharmacy ships the capsules in discreet packaging to your address in a state CLYR serves.
- Ongoing contact. You can message your provider through the patient portal with questions or side effects, and reorder when your provider says it is appropriate.
What to check in any LDN service
Online LDN is offered by many companies. Whatever service you use, these are the basics worth confirming before you pay.
- Licensed providers. A real clinician, licensed in your state, should review your history before anything is prescribed.
- A real screening. The intake should ask about your medicines, liver health, pregnancy and allergies. A checkout with no health questions is a warning sign.
- A licensed U.S. compounding pharmacy. The label should name the pharmacy, the prescriber, the drug and the strength.
- Verification. LegitScript certification is one independent check that a telehealth company follows pharmacy and advertising rules. CLYR is LegitScript certified.
- A clear price. You should know the total before checkout, including any visit fee, membership and shipping.
- No surprise renewals. If a plan renews automatically, the terms should be stated plainly. At CLYR, nothing renews.
What it costs at CLYR
At CLYR, low-dose naltrexone 4.5 mg is $119 for 30 capsules or $169 for 90 capsules. Each order is billed once and nothing renews. Provider review and shipping are included, and your provider sets the days of supply. Compounded LDN is usually paid out of pocket, and CLYR is cash-pay. For a closer look at pricing and how to compare services fairly, read how much LDN costs.
Who will not be prescribed LDN
Some people are not candidates for naltrexone at any dose. Liver disease, hepatitis or abnormal liver tests, a known allergy to naltrexone, and certain medicines that cannot be combined with it all rule it out. The full list is in the Important Safety Information and in the safety section at the end of this article. Be complete and honest in your screening, because your provider relies on it.
Where CLYR ships
CLYR ships to most states and Puerto Rico. Because telehealth rules vary by state, the current list is kept on the LDN page, and the intake checks your state before anything else.
Frequently asked questions
Can I get LDN online?
Yes, through telehealth services with licensed providers. You complete a screening, a provider reviews it, and a pharmacy ships the medicine if it is prescribed.
How much does LDN cost at CLYR?
$119 for 30 capsules or $169 for 90 capsules. Billed once, nothing renews, and provider review and shipping are included. Your provider sets the days of supply.
Does insurance cover LDN?
Compounded LDN is usually paid out of pocket. CLYR is cash-pay.
Is LDN FDA-approved?
No. LDN is compounded by a licensed pharmacy and prescribed off-label. Compounded medicines are not FDA-approved and have not been reviewed by the FDA for safety or effectiveness.
Which states does CLYR ship to?
Most states and Puerto Rico. The current list is on the LDN page.
Important safety information
Compounded low-dose naltrexone is a prescription capsule dispensed only after a licensed provider independently reviews your intake and determines it is appropriate for you. Do not take naltrexone if you take any opioid medicine or have taken one in the last 14 days, including tramadol, codeine, methadone or buprenorphine, because naltrexone blocks them and can cause sudden withdrawal; do not take it if you currently take or need opioid medicines, have liver disease, hepatitis or abnormal liver tests, or are allergic to naltrexone. Tell your provider about kidney disease, pregnancy, breastfeeding or plans for pregnancy, and about every medication and supplement you take. Side effects may include vivid dreams, trouble sleeping, headache, nausea, dizziness or anxiety. Carry a note that you take naltrexone, because opioid pain medicines may not work normally while it is in your system. Compounded medications are made by a licensed U.S. 503A pharmacy to a provider's prescription; they are not FDA-approved and have not been reviewed by the FDA for safety or effectiveness. Individual results vary. Not everyone qualifies. This page is informational and is not medical advice. Call 911 in an emergency.
The same text appears in the Important Safety Information on the LDN page.