Ask CLYR: At CLYR, LDN 4.5 mg costs $119 for 30 capsules or $169 for 90 capsules. You are billed once and nothing renews. Provider review and shipping are included, and your provider sets the days of supply. Compounded LDN is usually not covered by insurance.
Low-dose naltrexone (LDN) is a compounded capsule, not FDA-approved at this dose, and prescribed off-label. Because it is compounded, the price depends on who prescribes it, which pharmacy makes it, and what else is bundled in. This guide covers what LDN costs at CLYR, what that price includes, why insurance rarely pays for it, and how to compare offers without getting caught by add-on fees. For background on the medicine itself, see what low-dose naltrexone is.
The short answer
At CLYR, low-dose naltrexone 4.5 mg is $119 for 30 capsules or $169 for 90 capsules. Each order is billed once and nothing renews. Provider review and shipping are included, and your provider sets the days of supply. There is no membership and no subscription.
What is included at CLYR
| Item | Included? |
|---|---|
| Review of your screening by a licensed provider | Yes |
| Compounded naltrexone 4.5 mg capsules from a licensed U.S. 503A pharmacy | Yes, 30 or 90 capsules |
| Shipping to most states and Puerto Rico | Yes |
| Messaging your provider through the patient portal | Yes |
| Membership fee | None |
| Automatic renewal | None. Each order is billed once |
| Days of supply | Set by your provider in your directions |
Why insurance rarely covers LDN
Insurance plans generally cover FDA-approved medicines used for their approved purposes. LDN is a compounded capsule prescribed off-label, so it usually falls outside that coverage. Some people use health savings or flexible spending accounts for prescriptions; check your plan's rules. CLYR is cash-pay and does not bill insurance.
How to compare LDN prices fairly
A low headline price can hide other costs. Put every offer on the same footing before you decide.
- Compare per capsule and per strength. Check the strength in milligrams as well as the capsule count, since a price for a different strength is not directly comparable.
- Check what the price includes. Is the provider review included, or billed as a separate visit fee? Is shipping added at checkout?
- Look for memberships. Some services charge a recurring membership on top of the medicine.
- Check for auto-renewal. Subscriptions keep billing until you cancel. Read the terms before you buy.
- Check the pharmacy. The capsules should come from a licensed U.S. compounding pharmacy, with a proper label naming the prescriber and the strength.
Reviews note that naltrexone itself is an inexpensive molecule (Toljan and Vrooman, 2018). Most of the difference between services comes from fees, packaging and how the plan is billed, not from the medicine.
Get started
If you want to find out whether LDN is appropriate for you, the first step is a health screening. You can see LDN pricing and start your screening, or read how getting LDN online works first.
Frequently asked questions
How much does LDN cost at CLYR?
$119 for 30 capsules or $169 for 90 capsules, billed once. Nothing renews.
Is this a subscription?
No. Each order is billed once and nothing renews. You reorder when your provider says it is appropriate.
What is included in the price?
Provider review, the compounded 4.5 mg capsules, and shipping.
Does insurance pay for LDN?
Usually not, because LDN is compounded and prescribed off-label. CLYR is cash-pay.
How long do the capsules last?
Your provider sets the days of supply in your directions. The dose itself is explained in LDN dosing: why 4.5 mg.
Important safety information
Compounded low-dose naltrexone is a prescription capsule dispensed only after a licensed provider independently reviews your intake and determines it is appropriate for you. Do not take naltrexone if you take any opioid medicine or have taken one in the last 14 days, including tramadol, codeine, methadone or buprenorphine, because naltrexone blocks them and can cause sudden withdrawal; do not take it if you currently take or need opioid medicines, have liver disease, hepatitis or abnormal liver tests, or are allergic to naltrexone. Tell your provider about kidney disease, pregnancy, breastfeeding or plans for pregnancy, and about every medication and supplement you take. Side effects may include vivid dreams, trouble sleeping, headache, nausea, dizziness or anxiety. Carry a note that you take naltrexone, because opioid pain medicines may not work normally while it is in your system. Compounded medications are made by a licensed U.S. 503A pharmacy to a provider's prescription; they are not FDA-approved and have not been reviewed by the FDA for safety or effectiveness. Individual results vary. Not everyone qualifies. This page is informational and is not medical advice. Call 911 in an emergency.
The same text appears in the Important Safety Information on the LDN page.