Testosterone 1% cream (10 mg per gram) applied to shoulders, upper arms, or inner thighs provides needle-free androgen replacement. A typical starting dose delivers 50 to 100 mg testosterone daily (5 to 10 grams of cream), titrated to morning total testosterone and symptom response.
Absorption and variability
Transdermal delivery avoids injection peaks and troughs but shows higher inter-patient variability than cypionate. Skin thickness, application site, and adherence affect levels. Washing hands after application and covering skin until dry prevents transfer to partners and children, a serious safety issue with topical androgens.
Who chooses cream
Needle-averse patients, those with injection site reactions, or men wanting daily fine-tuning. Fertility preservation is not better with cream than injection; both suppress the HPG axis at therapeutic doses.
Monitoring
Same as injectable TRT: hematocrit, PSA, lipids, symptom review. Apply to clean dry skin; rotate sites. Compounded 30g tubes are standard telehealth packaging.
CLYR Health offers testosterone 1% cream as a men's hormone preview SKU.