Testosterone is the most abundant biologically active sex steroid in women across the lifespan, peaking in the 20s and declining with age and menopause. Hypoactive sexual desire disorder (HSDD) in postmenopausal women with distress has modest evidence for transdermal testosterone in guideline reviews, though no FDA-approved female testosterone exists in the US as of 2026.
Compounded low-dose creams (targeting 0.5 to 1 mg daily absorbed testosterone, far below male TRT) aim for mid-range female physiologic levels. Benefits may include improved libido, energy, and muscle maintenance; risks include acne, hair growth, voice deepening if overdosed, and HDL reduction.
Monitor total testosterone, hematocrit, lipids, and clinical virilization signs. Avoid in pregnancy and hormone-sensitive cancers without oncology input.
CLYR Health offers women's testosterone cream as a preview SKU for individualized androgen protocols.