MICC is the name telehealth weight programs use for a compounded injection of four nutrients: Methionine, Inositol, Choline, and Cyanocobalamin, a form of vitamin B12. You will also see it called MIC + B12 or Lipo-B. It is described as lipotropic, meaning its ingredients are involved in how the liver processes and moves fat. It is not a GLP-1 medication and it is not a weight loss drug on its own. It is prescribed as a companion inside a medically guided weight plan, most often alongside a GLP-1.

The short answer

A MICC B12 injection combines three lipotropic nutrients with vitamin B12 in one small shot. At CLYR, MICC + B12 is prescribed online by a licensed provider and costs $110 for one 10mL vial, billed once. Provider consultation, syringes, and shipping are included, nothing renews, and the vial stores at room temperature.

What each component does

Methionine is an essential amino acid the body cannot make on its own. It is a precursor to S-adenosylmethionine (SAMe), the body's main methyl donor, and takes part in the chemistry the liver uses to process fats.

Inositol is a sugar-like compound found in cell membranes. It plays a part in cell signaling, including insulin signaling, and in phospholipid synthesis. Most of the research on inositol studies oral doses measured in grams, so it does not describe what a small injected amount does.

Choline is an essential nutrient the liver needs to package and export fat as very-low-density lipoprotein (VLDL). When choline intake is too low, fat can build up in the liver. The National Academies set an adequate intake for choline for that reason.

Cyanocobalamin (B12) is a stable form of vitamin B12. The body uses B12 to make red blood cells, maintain nerves, and turn food into usable energy. People with a documented B12 deficiency are treated with B12 replacement at doses their clinician sets, which may differ from the amount in a MICC vial.

At CLYR, each mL of MICC contains methionine 25mg, inositol 50mg, choline 50mg, and cyanocobalamin 0.33mg.

MICC B12 vs a plain B12 shot

A B12 shot has one active ingredient. MICC has four: the same B12 plus methionine, inositol, and choline. A third option, Lipo-Mino + L-Carnitine, keeps the methionine, inositol, and choline base, swaps the single B12 for a B-complex (B1, B2, B6), and adds L-carnitine, for seven actives per mL. For a side-by-side of formula, schedule, storage, and price, see Lipo-Mino vs MICC.

Evidence and expectations

MICC has no FDA-approved weight loss indication and has not been studied in large weight loss trials. Its popularity comes from clinic practice rather than from registration studies. The individual ingredients have their own evidence: choline requirements from the Institute of Medicine, inositol studies in insulin resistance, and B12 replacement in deficiency. That evidence is about the nutrients, not about the finished injection as a weight loss treatment.

The honest expectation is that MICC is a supporting nutrient injection, not a driver of weight loss. Progress on a weight plan still depends on the plan itself, including any GLP-1 medication, nutrition, protein, and activity. Some patients report more energy; others notice little change. Individual results vary.

How it is taken

MICC is a small intramuscular or subcutaneous injection of 1mL at a time, on the schedule your provider writes. CLYR's page notes that once or twice a week is typical, and one 10mL vial lasts about a month at the usual schedule. Your provider decides the dose, the schedule, and whether it goes in a muscle or under the skin. Most patients self-administer at home in under a minute, with syringes and alcohol pads included.

Using MICC with compounded semaglutide or tirzepatide

CLYR's compounded semaglutide and tirzepatide are already compounded with B12. MICC is a separate, optional companion that a provider may add for patients who want the lipotropic nutrients too. Pairing it with a GLP-1 is the most common way it is prescribed. Your provider sets the timing; most patients keep MICC on a different day from their GLP-1 injection. Do not add or stack injections on your own.

What MICC costs through CLYR

Prices as listed on the MICC + B12 page:

Multi-vial plans are one prescription with a vial shipped each month. Every plan includes the vial, an injection homekit (syringes and alcohol pads), a licensed provider consultation, ongoing care and dose questions, and free expedited shipping in plain packaging. Nothing renews. MICC ships and stores at room temperature, away from light.

How to get MICC prescribed online

  1. Health questionnaire. About five minutes, online.
  2. Provider review. A licensed provider reviews your health profile and, if MICC is appropriate, writes the dose and schedule.
  3. Made and shipped. The vial is made in a U.S. 503B outsourcing facility, dispensed by a state-licensed pharmacy, and shipped with your homekit.
  4. Ongoing care. Schedule changes, side effect questions, and timing around a GLP-1 are one message away.

Safety and who should not use it

The most common side effects listed on CLYR's page are irritation or redness at the injection site and, occasionally, temporary fatigue or nausea. Anything severe, or any sign of an allergic reaction, means stop and contact your provider or seek care.

MICC is not for anyone with severe liver or kidney disease, anyone pregnant or breastfeeding, or anyone with a known allergy to any ingredient, including cobalt or B12. Your provider screens for these at consultation. Tell your provider about every medication and condition you have.

Frequently asked questions

What does MICC stand for?

Methionine, inositol, choline, and cyanocobalamin (vitamin B12). The first three are lipotropic nutrients; B12 is there for energy metabolism and red blood cells.

Is MICC B12 a weight loss drug?

No. It is a nutrient injection prescribed as a companion inside a medically guided weight plan. It does not replace a GLP-1 or drive weight loss on its own.

How much does a MICC injection cost at CLYR?

$110 for one 10mL vial, $315 for three, or $600 for six, billed once. Provider consultation, syringes, and shipping are included, and nothing renews.

Can I use MICC with compounded semaglutide or tirzepatide?

That is the most common way it is prescribed. Your provider sets the timing; most patients keep it on a different day from their GLP-1.

Do I need to see a doctor in person?

No. A licensed provider reviews your online questionnaire and, if appropriate, writes the prescription.

Does MICC need refrigeration?

No. CLYR's MICC ships and stores at room temperature, away from light.

How is MICC different from a plain B12 shot?

A B12 shot has one active ingredient. MICC adds three lipotropic nutrients, methionine, inositol, and choline, to the B12.

The bottom line

MICC is a four-nutrient companion injection, not a weight loss drug. Its ingredients have real roles in fat processing and energy metabolism, but the finished injection has not been proven as a weight loss treatment, so it belongs inside a provider-guided plan. If you want it prescribed online with the price shown up front, start the MICC consultation (three vials, $315 billed once) or compare plans on the MICC + B12 page. On a GLP-1 already? See tirzepatide and semaglutide.

Medical disclaimer

This article is for educational purposes only and is not medical advice, diagnosis, or treatment. MICC + B12 is a compounded prescription medication dispensed only after a licensed provider independently reviews your intake and determines it is appropriate for you. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety or effectiveness. MICC is not a weight loss drug and has no FDA-approved weight loss indication. Not everyone qualifies, and individual results vary. Available in most states. Call 911 in an emergency.