Genitourinary syndrome of menopause (GSM) affects up to 50% of postmenopausal women, vaginal dryness, pain with intercourse, recurrent UTIs, and urgency. Low-dose vaginal estradiol cream 0.01% (1 mg/g) delivers estrogen directly to urogenital tissue with serum levels typically staying within postmenopausal range at standard doses.
Loading schedules (daily for 2 weeks) then twice-weekly maintenance restore vaginal epithelium, pH, and elasticity. Systemic hot flash treatment is not the goal; local GSM symptoms are. Many breast cancer survivors can use local estrogen after oncology clearance, an individualized decision.
CLYR Health offers estradiol vaginal cream as a women's hormone preview SKU.